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作为肿瘤标志物的AFP(甲胎蛋白),是诊断肝细胞癌不可缺少的一项检查方法。但肝硬化时,常伴有AFP 轻度升高。因此,鉴别诊断困难的情况并不少见,近年已报告。AFP 糖链差异所致的异质性,发现依植物血凝素有无结合性,能区别肝脏的良、恶性疾病,肝癌产生的AFP 常与小扁豆植物血凝素(LCH)呈结合性,而肝脏良性疾病所产生的AFP 型LCH 呈非结合性。因此,利用这一特性可用以诊断肝癌。作者收集经血管造影确诊的5例肝癌患者,研究时AFP 值均小于250ng/ml,其中3例肿瘤
AFP (alpha-fetoprotein) as a tumor marker is an indispensable method for diagnosing hepatocellular carcinoma. However, cirrhosis is often accompanied by a slight increase in AFP. Therefore, it is not uncommon for differential diagnosis to be difficult and have been reported in recent years. The heterogeneity caused by the difference in AFP sugar chains was found to depend on the presence or absence of phytohemagglutinin binding and to discriminate between benign and malignant diseases of the liver. AFP produced by liver cancer is often combined with lentil lectin (LCH). The AFP-type LCH produced by benign liver disease is non-binding. Therefore, using this feature can be used to diagnose liver cancer. The authors collected 5 cases of liver cancer patients diagnosed by angiography. The AFP values were less than 250ng/ml during the study, including 3 tumors.