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60只纯种ICR小鼠喂服CCI_4每周1次,共2次,致中毒性肝坏死。随机分为3组,分别喂以秋水仙碱0.5μg、泼尼松10μg和蒸溜水(对照组),每日1次,共14次。另以ICR小鼠14只作空白对照。3个实验组死亡率各为25％、50％和35％。泼尼松组和对照组雌、雄鼠死亡数相近,但秋水仙碱组雄鼠无死亡。各鼠肝剖验镜检以秋水仙碱组脂肪变性及坏死少且程度轻,未发现纤维组织增生。泼尼松组和对照组除肝脏病变明显外,各有2只和3只鼠肝见纤维组织增生。示秋水仙碱治疗似可降低中毒性肝坏死的雄鼠死亡率,减轻小鼠肝脏病理改变,防止肝脏纤维化。泼尼松则否。
60 purebred ICR mice were fed CCI_4 once a week for a total of 2 times, resulting in toxic hepatic necrosis. They were randomly divided into 3 groups and fed with colchicine 0.5 μg, prednisone 10 μg and distilled water (control group) once a day for 14 times. In addition, 14 ICR mice were used as blank controls. The mortality in the three experimental groups was 25%, 50%, and 35%. The number of deaths of male and female rats in the prednisone group was similar to that in the control group, but there was no death in the male rats in the colchicine group. Each rat liver biopsy showed that the colchicine group had less steatosis and necrosis and was mild, and no fibroplasia was found. In the prednisone group and the control group, fibrous tissue hyperplasia was observed in livers of 2 and 3 rats except for liver lesions. Shows that colchicine treatment seems to reduce the mortality of male mice with toxic liver necrosis, reduce liver pathological changes in mice, and prevent liver fibrosis. Prednisone is not.