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目的通过分析少精子症和严重少精子症患者的Y染色体微缺失情况及其体外受精/卵胞浆内单精子注射(IVF/ICSI-ET)妊娠结局以及后代情况,探讨AZF微缺失对辅助生殖妊娠结局以及出生后代的影响。方法实验组中488例少精子症和严重少精子症患者行Y染色体微缺失检测,将缺失携带者作为A组,将非携带患者作为B组。有正常生育能力,并有自然生育史的125例男性纳入对照组(C组)。对比A组、B组以及C组的妊娠结局和出生后代指标差异。结果实验组中488例少精子症和严重少精子症患者中,Y染色体微缺失者共56例,均为AZFc微缺失,其中14例(25%)表现为少精子症,42例(75%)表现为严重少精子症。A组、B组和C组妊娠结局以及对子代影响的指标,3组间两两比较后均显示差异无统计学意义。结论 Y染色体微缺失对IVF/ICSI-ET治疗周期形成的妊娠结局以及出生后代无显著性影响。
Objective To investigate the effects of AZF microdeletions on assisted reproduction (GFP) by analyzing the status of Y chromosome microdeletions in patients with oligospermia and severe oligozoospermia as well as the pregnancy outcome and in vitro fertilization / IVF / ICSI-ET Pregnancy outcome and the impact of offspring. Methods 488 cases of oligozoospermia and severe oligospermia patients in the experimental group were detected by Y chromosome microdeletions, the carrier of deletion as A group, and the non-carrier group as B group. A total of 125 men with normal fertility and a natural history of fertility were included in the control group (group C). The differences of pregnancy outcome and offspring progeny between group A, group B and group C were compared. Results Among the 488 oligozoospermia and severe oligospermia patients, 56 patients with Y chromosome microdeletion were AZFc microdeletions, of which 14 (25%) showed oligozoospermia and 42 (75% ) Showed severe oligozoospermia. The pregnancy outcome in group A, group B and group C as well as the index of influence on offspring showed no significant difference after each comparison among the three groups. Conclusion Y chromosome microdeletions have no significant effect on the outcome of pregnancy and the offspring of IVF / ICSI-ET treatment.