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1.耳的毒性:急性听力下降,其机理未明,多发生于尿毒症或氮质血症的病人应用大剂量时,亦有报告二例肾功能正常者仅用利尿酸50毫克时也发生。这些病人均同时应用对耳有毒性作用的氨基甙类抗菌素,故认为利尿酸应避免与上述药物联合应用。听力下降一般发生在静注后10～15分钟,利尿酸引起听力下降一般在数小时内恢复。然而曾有永久性听力下降包括双侧耳聋的报告。但速尿引起听力减退则没有报告过。此外,两者还可有暂时性耳鸣和晕眩。速尿所致的毒性作用与给药速度有关,作者等主张,静脉注射速尿的速度应小于4毫克/分。利尿酸
1. Ear toxicity: acute hearing loss, the mechanism is unknown, occurred in patients with uremia or azotemia when using large doses, there are also reports of two cases of normal renal function with only 50 mg of uric acid also occurred. These patients are simultaneously applied to the toxic effects of aminoglycosides antibiotics, it is believed that the combination of uric acid should be avoided with these drugs. Hearing loss usually occurs 10 to 15 minutes after intravenous injection, diuretic acid causes hearing loss usually within a few hours to recover. However, there have been reports of permanent hearing loss including bilateral deafness. However, furosemide-induced hearing loss has not been reported. In addition, both may have temporary tinnitus and dizziness. The toxic effects of furosemide are related to the drug delivery rate. The authors claim that the speed of intravenous furosemide should be less than 4 mg / min. Uric acid