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恶性疟高度流行区最高的发病率和严重的临床发作多见于一岁后期。而一岁的头几个月的婴儿是具有抗疟疾发病保护性的。这些地区的成人也能控制高密度虫源,并具有抗重症疟疾的保护性,至少婴儿可部分地从母亲处获得抗体介导的临床保护。然而,特异性抗疟疾免疫球蛋白IgG在婴儿的天然免疫水平中的重要性尚不清楚,若疫苗接种有效那么其靶是什么?为此作者在坦桑尼亚南部Kilomber县的Idete村对198名婴儿(小于4个月龄者83名,5~11个月115名)进行研究。
The highest incidence and serious clinical seizures of the highly endemic areas of falciparum malaria are most common in the first year of life. In the first months of life, babies are protective of malaria. Adults in these areas are also able to control high-density insect sources and have protection against severe malaria, at least in part for infant-derived antibody-mediated clinical protection from their mothers. However, the importance of specific anti-malarial immunoglobulin IgG in infants’ innate immunity remains unclear. What is the target if the vaccination is effective? For this reason, the author of 198 infants in the village of Idete in Kilomber County, southern Tanzania, 83 less than 4 months old and 115 in 5 to 11 months).