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目的探讨成人室管膜瘤的临床及病理学特点。方法收集30例发生于成人的室管膜瘤,分析其临床及病理学特点,免疫组织化学EnVisionTM染色及电子显微镜观察形态学特征。结果患者临床表现多样,不同部位肿瘤患者症状有所不同。标本最常见的病理表现为血管周围假菊形团形成,瘤细胞呈放射状排列在血管周围,形成血管周围无细胞核区。部分标本还可见室管膜裂隙和室管膜菊形团。17例进行了免疫组织化学染色,结果显示大部分瘤细胞表达胶质纤维酸性蛋白(GFAP)、S-100和肿瘤细胞对中型丝(vimentin);部分瘤细胞表达上皮细胞膜抗原(EMA),阳性信号主要分布于室管膜菊形团的腔面,呈线、点状分布。结论室管膜瘤是一种有特殊组织结构的神经上皮肿瘤,其最主要的组织病理学特点为血管周围假菊形团和室管膜菊形团,掌握其临床及病理学特点对该病的诊断及治疗有重要意义。
Objective To investigate the clinical and pathological features of adult ependymoma. Methods Thirty adult patients with ependymoma were collected and analyzed for clinical and pathological features. Immunohistochemistry EnVisionTM staining and electron microscopy were used to observe morphological characteristics. Results The clinical manifestations of patients varied, different parts of the tumor patients have different symptoms. Specimens the most common pathological manifestations of the formation of pseudo-daisy perivascular formation, tumor cells arranged radially around the blood vessels, the formation of perivascular nuclei. Some specimens also visible ependymal fissures and ependymal chrysoid groups. Immunohistochemical staining of 17 cases showed that most tumor cells expressed glial fibrillary acidic protein (GFAP), S-100 and tumor cells to vimentin; some tumor cells expressed epithelial cell membrane antigen (EMA), which was positive The signal is mainly distributed in the luminal surface of the ependymal chrysotile, which is in line and dot shape. CONCLUSION: Ependymoma is a kind of neuroepithelial neoplasm with special histological structure. Its main histopathological features are the pseudo-daisy and ependymal damascene perivascular tissue, and its clinical and pathological characteristics of the disease Diagnosis and treatment are of great significance.