【摘 要】
：
调查了583例精神分裂症患者及372例健康人,对NPY(neuropeptide Y)及YWHAH(14-3-3 eta chain gene)基因中几个已报道过的阳性关联位点进行了检测.YWHAH基因上的-134(GCCTGCA)2
【机 构】
：
上海交通大学Bio-X生命科学研究中心,中国科学院上海生命科学研究中心营养科学研究所,上海市精神卫生中心,宁夏大学生命科学学院
论文部分内容阅读
调查了583例精神分裂症患者及372例健康人,对NPY(neuropeptide Y)及YWHAH(14-3-3 eta chain gene)基因中几个已报道过的阳性关联位点进行了检测.YWHAH基因上的-134(GCCTGCA)2～4位点因扩增失败未能考察,NPY基因上的T1128C位点在样本中则不存在.重点对-485C>T(NPY)和G753A(YWHAH)两个位点进行了分析,各相匹配组间比较均未发现等位型频率(P值分别是0.696 和 0.743,OR值分别是 1.041 和 0.962)和基因型频率(P值分别是 0.45 和0.75,χ2值分别是1.51 和 0.58)的显著性差异.对两个基因之间的基因型相对风险分析表明,它们也不能协同导致疾病风险(P>0.05).结果提示,在中国汉族人群中-485C>T(NPY)和G753A(YWHAH)两个多态性位点与精神分裂症的遗传易感性不存在关联.
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