中药心得宁口服液对水负荷大鼠模型的影响

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目的:观察心得宁口服液对水负荷大鼠模型的影响。方法:取筛选合格的大鼠70只随机分为7组,每组10只;分别灌服心得宁口服液(20,10,5 ml·kg-1)、呋塞米片混悬液(0.033 5 mg·ml-1)、芪苈强心胶囊混悬液(0.03 g·ml-1)和等体积的蒸馏水(模型组)。空白组不灌服。将大鼠放入代谢笼,每隔1 h记一次尿量,共计5 h,收集给药后5 h的总尿量,测尿液中Na+、K+、Cl-的浓度。结果:与空白组比,模型组在2,3,5 h尿量均显著增加(P<0.01),总尿量也显著增加(P<0.01),尿液中K+浓度明显减少(P<0.05)、尿液中Na+、Cl-浓度有增加趋势,说明造水负荷模型成功。与模型组比,呋塞米可显著升高大鼠1,2,3,4,5 h尿量和总尿量(P<0.01),芪苈强心胶囊组尿液中K+浓度明显升高(P<0.05),呋塞米组尿液中K+浓度明显降低(P<0.05),大剂量心得宁口服液可显著升高大鼠5 h尿量(P<0.01)以及尿液中Na+、Cl-的浓度(P<0.01);中剂量心得宁口服液可明显升高大鼠3 h及5 h尿量和总尿量(P<0.05)及尿液中Cl-的浓度(P<0.05);小剂量心得宁口服液组中Na+、Cl-的浓度均显著降低(P<0.01)。与芪苈强心胶囊组比,心得宁口服液大、中、小剂量对1,2,3,4,5 h尿量和总尿量影响无明显差异(P>0.05);大剂量心得宁口服液可显著增加尿液中Na+浓度(P<0.01),中、小剂量心得宁口服液可明显增加尿液中Na+浓度(P<0.05);小剂量心得宁口服液可显著减少尿液中K+浓度(P<0.01);大、中剂量心得宁口服液可显著增加尿液中Cl-浓度(P<0.01),小剂量心得宁口服液可显著减少尿液中Cl-浓度(P<0.01)。与大剂量心得宁口服液组比,中、小剂量心得宁口服液对1h、2 h、3 h、4 h及5 h尿量影响无明显差异(P>0.05),但均可显著增加总尿量(P<0.01);中、小剂量心得宁口服液可显著较少尿液中Na+浓度(P<0.01)、可显著减少尿液中Cl-浓度(P<0.01)。结论:心得宁口服液有显著利尿作用且有量效关系。 Objective: To observe the effects of Xindening oral liquid on water load rat model. Methods: Seventy of the selected rats were randomly divided into 7 groups (n = 10 in each group). The rats were randomly divided into three groups: control group (20,10,5 ml · kg -1), suspension of furosemide tablets 5 mg · ml-1), Qiliqiangxin capsule suspension (0.03 g · ml-1) and an equal volume of distilled water (model group). Blank group is not fed. The rats were placed in metabolic cages and the urine volume was recorded every 1 h for a total of 5 h. The total urinary output was measured 5 h after the administration, and the concentrations of Na +, K + and Cl- in the urine were measured. Results: Compared with the blank group, the urinary output in model group increased significantly at 2, 3 and 5 hours (P <0.01) and the total urine output increased significantly (P <0.01) and the urine K + concentration decreased significantly (P <0.05 ), The concentration of Na + and Cl- in urine tends to increase, which indicates that the water-making load model is successful. Compared with the model group, furosemide significantly increased the urine volume and total urine volume of rats in 1, 2, 3, 4, 5 h (P <0.01), while the K + concentration in urine of rats in Qili Qiangxin capsule group was significantly increased (P <0.05). The concentration of K + in urine of furosemide group decreased significantly (P <0.05), while the high dose Xindeningning Oral Liquid could significantly increase the urine output of rats in 5 hours (P <0.01) and the levels of Na +, Cl- (P <0.01). The medium dose Xindening Oral Liquid can obviously increase the urinary output and total urine volume (P <0.05) and the urinary Cl- concentration (P <0.05) at 3 h and 5 h in rats; The concentrations of Na + and Cl- in the dose of “Xingdening Oral Liquid” group were significantly decreased (P <0.01). Compared with Qiliqiangxin capsule group, there was no significant difference (P> 0.05) in the amount of large, medium and small doses of Xindening oral liquid on the amount of urine and total urine volume in 1, 2, 3, 4, 5 h (P> 0.05) Oral liquid can significantly increase the concentration of Na + in urine (P <0.01). Small and middle dose of Nadesining Oral Liquid can significantly increase the concentration of Na + in urine (P <0.05) K + concentration (P <0.01). Large and medium doses of Xindening Oral Liquid can significantly increase the concentration of Cl- in urine (P <0.01). Small doses of Xindening Oral Liquid can significantly reduce the concentration of Cl- in urine (P <0.01) ). Compared with the high-dose Xindening oral solution group, there was no significant difference in the urine volume of middle and low-dose Xindening oral solution at 1h, 2h, 3h, 4h and 5h (P> 0.05), but both could significantly increase the total Urine volume (P <0.01); middle and small doses of Xindening oral liquid could significantly reduce the concentration of Na + in urine (P <0.01), and significantly reduce the concentration of Cl- in urine (P <0.01). Conclusion: Xindening oral liquid has significant diuretic effect and dose-effect relationship.
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