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目的使用振动反应成像(VRI)设备提供的双肺同步性指标对吸烟者和不吸烟者的肺部情况进行观察和分析,探讨VRI在发现和评价吸烟相关早期肺损害中的价值。方法随机选取来自北京市郊区某自然村的村民为研究对象。资料采集的具体步骤:(1)询问既往史及吸烟史;(2)呼出气一氧化碳(CO)检测确认受试者的吸烟状况;(3)VRI检测后,系统输出双肺各自呼吸能量随时间变化的曲线,计算双肺同步性差距;(4)肺功能检测。符合纳入标准的26例村民进入研究。根据吸烟史将受试者分为吸烟组与不吸烟组。比较两组双肺同步性差距的差异,分析两组肺同步性差距与吸烟指数及被动吸烟指数之间的关系。结果不吸烟组双肺呼吸能量单位(BEU)曲线同步性差距为2.0(3.0)帧,吸烟组同步性差距为2.0(3.0)帧,秩和检验提示吸烟组与不吸烟组双肺同步性差距差异不显著(Z=-0.29,P=0.77)。相关性分析提示在吸烟组中,吸烟指数(SI)与肺同步性差距存在显著相关性(r=0.61,P=0.03)。不吸烟组的被动吸烟指数(PSI)与双肺同步性差距之间相关系数r=0.52(P=0.07)。通过散点图可以观察到,不吸烟组中被动吸烟指数与双肺同步性差距之间存在着一定的相关趋势。结论 VRI提供的BEU曲线同步性差距这项新的观察指标在吸烟者中体现出了与吸烟强度之间的量效相关性,是否能够更进一步观察和量化吸烟者甚至被动吸烟者吸烟相关的早期肺损害还有待于更大样本的研究去证实。
Objective To observe and analyze the pulmonary conditions of smokers and non-smokers using the dual-lung synchronicity index provided by VRI equipment to explore the value of VRI in detecting and evaluating smoking-related early lung damage. Methods Randomly select villagers from a natural village in the suburbs of Beijing as the research object. (2) exhaled carbon monoxide (CO) test to confirm the subject’s smoking status; (3) VRI test, the system outputs the respiration energy of each lung with time Changes in the curve, calculate the gap between the two lungs; (4) lung function test. Twenty-six villagers who met the inclusion criteria entered the study. Subjects were divided into smoking group and non-smoking group according to smoking history. The differences of synchronicity between the two groups were compared, and the relationship between the difference of synchronicity and smoking index and passive smoking index between the two groups was analyzed. Results There was a 2.0 (3.0) frame difference in BEU curve synchronization between non-smoking groups and a 2.0 (3.0) frame synchronization gap between smoking groups. The rank sum test showed that there was no significant difference between the two groups in smoking-group and non-smoking group The difference was not significant (Z = -0.29, P = 0.77). Correlation analysis suggested that there was a significant correlation between smoking index (SI) and pulmonary synchronicity in the smoking group (r = 0.61, P = 0.03). The correlation coefficient between passive smoking index (PSI) and binocular synchronization difference of non-smoking group was 0.52 (P = 0.07). It can be observed by scatter chart that there is a certain relative trend between the passive smoking index and the synchronicity of the two lungs in the non-smoking group. Conclusions The BEI Curves Synchronization Gap provided by VRI This new observation shows the dose-response relationship between smokers and smoking intensity and whether they can further observe and quantify the smoking-related early stage of smokers and even passive smokers Lung damage remains to be confirmed by larger studies.