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目的探讨多发性硬化(multiple sclerosis,MS)患者脑和脊髓磁共振成像(magnetic resonance imaging,MRI)的特征及其与生活质量、残疾程度等因素的关系。方法对170例临床诊断多发性硬化患者进行MRI检查,并进行生活质量、残疾状况、焦虑和抑郁状态评分。结果脑内病变部位以侧脑室旁、半卵圆中心和额叶多见;脊髓单病灶以1~2个椎体长度多见,融合病灶以4~5个椎体长度多见;视神经脊髓炎(neuromyelitis optica,NMO)、MS脑脊髓混合损害和单纯脊髓损害3种类型的比较,NMO患者的脊髓病灶最长;MS患者的生活质量、神经功能缺失程度、焦虑和抑郁受病灶的分布影响。结论MRI检查有利于MS的早期诊断和提高诊断的准确率,指导临床治疗,改善患者的预后和生活质量。
Objective To investigate the characteristics of brain and spinal magnetic resonance imaging (MRI) in patients with multiple sclerosis (MS) and its relationship with quality of life, degree of disability and other factors. Methods 170 cases of clinical diagnosis of multiple sclerosis patients underwent MRI examination, and quality of life, disability, anxiety and depression score. Results The lesion in the brain was found mostly in the lateral ventricle, the center of the semiovale and the frontal lobe. Spinal cord lesions were more common in 1-2 vertebral bodies and 4-5 vertebral bodies in the fusion lesion. The optic neuromyelitis (NMO), mixed cerebrospinal fluid (MS) and simple spinal cord injury (MSO). NMO patients had the longest lesions in the spinal cord. The quality of life, neurological deficit, anxiety and depression in MS patients were affected by the distribution of lesions. Conclusion MRI is helpful for the early diagnosis of MS and the accuracy of diagnosis, guiding the clinical treatment and improving the prognosis and quality of life of patients.