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目的 :探讨血清透明质酸 (HA)、 型胶原 ( - C)联合检测对肝纤维化诊断的准确性。方法 :运用放射免疫法 (RIA)测定 98例慢性肝炎患者血清 HA、 - C水平 ,并与临床 B型超声检查结果进行对比研究。结果 :二项指标升高与肝纤维组织增生程度呈良好的正相关 (P<0 .0 1)。二项指标分别在慢性肝炎中型、慢性肝炎重型以及肝硬化中渐次升高 ,有显著差异 (P<0 .0 1)。同期 B超检查结果准确率不高。结论 :二项指标的联合检测在肝纤维化和早期肝硬化的诊断上较 B超检查准确、可靠。
Objective: To investigate the diagnostic value of serum hyaluronic acid (HA) and collagen (- C) in the diagnosis of hepatic fibrosis. Methods: Serum HA and - C levels were measured in 98 patients with chronic hepatitis B by radioimmunoassay (RIA), and compared with clinical B - mode ultrasound findings. Results: The increase of binomial index was positively correlated with the degree of hepatic fibrosis (P <0.01). The two indexes gradually increased in chronic hepatitis with chronic hepatitis, severe hepatitis and cirrhosis, there was a significant difference (P <0.01). Over the same period B ultrasound examination results are not high accuracy. Conclusion: The combined detection of the two indexes is more accurate and reliable than B ultrasound in the diagnosis of liver fibrosis and early cirrhosis.