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目的:分析体重指数(BMI)对广西防城地区男性血清PSA水平的影响。方法:选择在2009年9月至2011年12月健康体检男性作为研究对象,测量身高、体重,并计算BMI,静脉血血清检测PSA水平。将研究对象分为低体重(BMI<18.5 kg/m2)、正常(BMI 18.5~22.9 kg/m2)、超重(BMI 23.0~27.4 kg/m2)、肥胖(BMI≥27.5 kg/m2)4组;进一步按年龄分为20~29、30~39、40~49及≥50岁4组,方差分析分别比较各BMI组内PSA水平差异。结果:符合标准、资料完整者2 397例,年龄(37.4±11.0)岁,BMI(23.3±3.4)kg/m2,PSA(0.98±0.93)μg/L。各BMI组PSA水平差异有统计学意义(P均<0.05)。各年龄组按照BMI分组比较,除≥50岁年龄组外,其余3组中PSA水平均随BMI增加而降低,但仅30~39岁和40~49岁年龄组内各BMI组别间的PSA水平差异有统计学意义(P<0.01)。结论:PSA随着BMI的增加而降低,这种趋势在中青年人群中比较明显。因此针对中青年群体,在依据PSA水平判断是否需要取前列腺组织行前列腺癌早期诊断时,更有必要考虑BMI的影响。
Objective: To analyze the influence of body mass index (BMI) on the level of serum PSA in men in Fangcheng, Guangxi. Methods: From September 2009 to December 2011, healthy male subjects were selected as subjects, height and weight were measured, BMI was calculated, and serum PSA level was measured. Subjects were divided into four groups: low body weight (BMI <18.5 kg / m2), normal (BMI 18.5-22.9 kg / m2), overweight (BMI 23.0-27.4 kg / m2) and obesity (BMI 27.5 kg / m2) Further divided into four groups of 20-29, 30-39, 40-49 and ≥50 years by age, and variance analysis was used to compare PSA levels in each BMI group. Results: There were 2 397 cases with complete data, with a mean age of (37.4 ± 11.0) years, BMI (23.3 ± 3.4) kg / m2 and PSA (0.98 ± 0.93) μg / L. The PSA levels in each BMI group were significantly different (all P <0.05). In each age group, according to the BMI group, PSA levels in the other three groups decreased with the increase of BMI, except in the group of ≥50 years old. However, the PSA levels of each BMI group in the age groups of 30-39 and 40-49 only The difference was statistically significant (P <0.01). Conclusion: PSA decreases with the increase of BMI, which is more obvious in middle-aged and young people. Therefore, for young and middle-aged groups, it is more necessary to consider the impact of BMI when it is necessary to determine whether prostate cancer is needed for early diagnosis of prostate cancer based on PSA level.