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目的:对比地氟烷或丙泊酚麻醉对中年患者乳腺癌术后认知能力恢复的影响.方法:60例行乳腺手术的中年患者,ASA分级I~II级,随机分为地氟烷(D组)和丙泊酚组(P组),术中分别采用地氟烷或丙泊酚作为主要麻醉药物的全身麻醉.采用认知功能问卷和术后恢复量表法对患者术后2、48、72 h和1周的认知功能进行评定.结果:根据认知功能问卷,D组和P组患者术后72 h认知功能的恢复分别为65%和66%,术后1周分别为71%和72%.根据术后恢复量表,D组和P组术后2 h认知功能的恢复分别为52%和50%,术后48 h分别增加到71%和87%.结论:行乳腺手术的中年患者,无论是接受地氟烷还是丙泊酚麻醉,术后1周的认知能力均未完全恢复,两组的认知能力恢复无显著差异.“,”Objective: To compare the influence between desflurane and propofol anesthesia on postoperative cognitive recovery in middle-aged patients with breast cancer. Methods: 60 ASA I~II women undergoing breast surgery were randomly divided into desflurane group and propofol group. Cognitive recovery was evaluated by using the Cognitive Failure Questionnaire and a modifie-dversion of the Post-operative Quality of Recovery Scale. Results: According to Cognitive Failure Questionnaire, post-operative cognitive recovery was 65% and 66% at 72 h, and 71% and 72% at 1 week for the desflurane and the propofol groups, respectively. Recovery evaluated by Post-operative Quality of Recovery Scale was 52% and 50% at 2 h, increased to 71% and 87% at 48 h for the desflurane and the propofol groups, respectively. Conclusion: Cognitive was not completely recovery at the first week after surgery neither in desflurane nor propofol groups. There was no difference in overall cognitive recovery between the two groups.