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我们用单克隆抗体(McAb)和兔补体体外净化骨髓中残留白血病细胞后对5例普通型急性淋巴细胞性白血病(CALL)患者进行了自身骨髓移植(ABMT)。抽出的骨髓细胞经McAb55加兔补体两次处理后,CALL抗原(CALLA)阳性细胞清除率可达2～3个对数级,骨髓有核细胞及CFU-GM回收率分别为48.7％～96.9％和39.5％～95.7％。外周血白细胞于移植后11～16d开始回升,14～29d升至1×10~9/L以上。23～53d出洁净室。例3于移植后4个月白血病复发, 8.2个月死亡。另4例无病活存分别为19~+、18~+、12~+和6~+个月,远期疗效正在定期随访中。
After in vitro purification of residual leukemic cells in the bone marrow with monoclonal antibodies (McAb) and rabbit complement, we performed an autologous bone marrow transplantation (ABMT) in 5 patients with CALL. The extracted myeloid cells treated with McAb55 plus rabbit complement twice, CALL antigen positive (CALLA) positive cells clearance up to 2 to 3 logarithmic level, bone marrow cells and CFU-GM recovery rates were 48.7% to 96.9% And 39.5% ~ 95.7%. Peripheral blood leukocytes began to recover from 11 to 16 days after transplantation and rose to over 1 × 10 ~ 9 / L from 14 to 29 days after transplantation. 23 ~ 53d a clean room. Example 3 Leukemia relapsed 4 months after transplantation and died 8.2 months. The other 4 cases of disease-free survival were 19 ~ +, 18 ~ +, 12 ~ + and 6 ~ + months, long-term efficacy is regular follow-up.