盐酸苯胺醇致突变研究:Ⅰ.小鼠骨髓细胞染色体畸变试验

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用昆明种小白鼠40只,均分5组,雌雄各半。其中3组试验组,分别口服盐酸苯胺醇 LD<sub>50</sub>(400mg/kg)的1/4、1/16、1/40;1组给予环磷酰胺20mg/kg 作阳性对照;1组给予溶剂作阴性对照。每只动物观察50个骨髓细胞,计算结构和数目畸变的染色体数,所得数据用 X<sup>2</sup>检验进行显著性检验。3个试验组与阴性对照组比较差异不显著;阴性组与阳性组比较差异非常显著。表明盐酸苯胺醇对小鼠骨髓细胞染色体无致畸变作用。
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