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目的探讨脑性瘫痪(CP)的危险因素。方法对1426例CP患儿及等量对照儿童进行以医院为基础的1:1匹配病例对照研究,数据处理采用SAS6.12软件进行条件Logistic回归分析。结果单因素分析提示既往不良孕产史、早产、低出生体质量、双胎、新生儿肺炎、新生儿窒息、新生儿HIE、试管婴儿、高胆红素血症、围生期颅内出血与小儿CP的发生有关。多因素分析提示早产、低出生体质量、HIE是CP的主要危险因素。结论小儿CP的发生主要与多种围生期因素有关,应加强围生期保健,积极预防和消除各种致干预因素,以降低小儿CP的发病率。
Objective To explore the risk factors of cerebral palsy (CP). Methods A hospital-based 1: 1 matching case-control study was conducted in 1426 children with CP and children with equivalent control. The data were processed using conditional logistic regression analysis using SAS6.12 software. Results Univariate analysis showed that the past history of poor pregnancy, premature birth, low birth weight, twin, neonatal pneumonia, neonatal asphyxia, neonatal HIE, IVF, hyperbilirubinemia, perinatal intracranial hemorrhage and pediatric CP related to the occurrence. Multivariate analysis suggested that preterm birth, low birth weight, HIE is the main risk factor for CP. Conclusions The occurrence of CP in children is mainly related to various perinatal factors. Perinatal care should be strengthened and various interventional factors should be actively prevented and eliminated so as to reduce the incidence of CP in children.