甲状腺过氧化物酶(TPO)作为一种重要的甲状腺自身抗原,在自身免疫性甲状腺疾病(AITD)的发病机制中占有重要地位。大多数TPO-B细胞抗原决定簇是高度构象性的,并集中于一个有限的区域——免疫优势区(IDR)中,而TPO表位“指纹”也具有一定的指导意义。IDR定位仍不清楚,可能主要由TPO中MPO样区与CCP样区相接的区域高度折叠而构成。TPO中也存在少量的非IDR B细胞抗原决定簇和线性决定簇。TPO-B细胞抗原决定簇及IDR构成、分布、定位等问题的解决很可能有助于阐明AITDs的发病机制,并为开辟特异性分子治疗途径提供理论基础。 Thyroid peroxidase (TPO), as an important thyroid autoantigen, plays an important role in the pathogenesis of autoimmune thyroid disease (AITD). Most TPO-B cell epitopes are highly conformational and are localized in a limited area, the immunodominant region (IDR), while the TPO epitope “fingerprinting” is also of some guiding importance. IDR positioning remains unclear and may consist mainly of highly folded regions of the TPO where the MPO and CCP zones meet. There is also a small amount of non-IDR B-cell epitopes and linear determinants in TPO. The resolution of TPO-B cell epitopes, IDR composition, distribution and localization may help to elucidate the pathogenesis of AITDs and provide a theoretical basis for the development of specific molecular therapy pathways.