代谢综合征是一组以胰岛素抵抗为核心,包括腹型肥胖、高血压、血糖异常、血脂紊乱等多种代谢异常的疾病。过氧化物酶体增殖物激活受体(PPARs)是一种配体激活的核转录因子,属于细胞核受体超家族成员。研究显示,PPARs的两个重要亚型PPAR-α和PPAR-γ,其激动剂均能改善胰岛素抵抗、高血压、肥胖等。现就PPAR-α/γ激动剂在代谢综合征的协同作用重点讨论。 Metabolic syndrome is a group of insulin resistance as the core, including abdominal obesity, hypertension, abnormal blood glucose, dyslipidemia and other metabolic disorders. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors and are members of the nuclear receptor superfamily. Studies have shown that two major PPARs subtypes PPAR-α and PPAR-γ, its agonist can improve insulin resistance, hypertension, obesity and so on. The synergistic effect of PPAR-α / γ agonists on metabolic syndrome is now under discussion.