普通柜式热压灭菌柜是目前我国药厂及医院大输液生产使用的主要灭菌器械,其效果是肯定的[1]。然而,对于一些需快速降温的制剂品种如葡萄糖注射液、普鲁卡因注射液常因灭菌原因造成质量下降、毒性增加。经灭菌后的葡萄糖输液常因不能及时降温,造成输液中5-羟甲基糠醛含量超标,输 Ordinary cabinet autoclaves cabinet is currently the major sterilization equipment used in pharmaceuticals and hospitals in large infusion production, the effect is affirmative [1]. However, for some types of preparations that require rapid cooling, such as glucose injection, procaine injection often causes deterioration in quality and toxicity due to sterilization. Sterilized glucose infusion often can not be timely cooling, resulting in infusion of 5 - hydroxymethyl furfural content exceeded, lose