目的　探讨纳洛酮对流行性乙型脑炎的疗效。方法　纳洛酮每次０ ．０１ ｍｇ／ｋｇ ，用注射用水３ ～５ ｍｌ 稀释后静脉推注，每６ ｈ 一次，直至神志转清，个别极重者剂量可加倍（ 即每次０ ．０２ ｍｇ／ｋｇ） 。结果：治疗组３８ 例治愈３０ 例（７８ ．９ ％ ） ，对照组３５例治愈２０ 例（５７ ．１ ％ ） ，两组治愈率相比，有显著性差异（χ２ ＝ ４ ．０１ ， Ｐ＜ ０ ．０５） ，虽然两组总有效率无显著差异（χ２ ＝ ０ ．７５ ， Ｐ＞０ ．０５） ，但治疗组在控制抽搐、降温、催醒等方面优于对照组。 Objective To investigate the efficacy of naloxone on Japanese encephalitis. Method naloxone 0 each time. 01 mg / kg, diluted 3 ~ 5 ml with water for injection intravenously every 6 h, until consciousness clear, the individual extremely heavy dose can be doubled (that is, each 0.02 mg / kg). Results: In the treatment group, 38 cases were cured (78.9%) and 35 cases were cured (20 cases, 57.1%). There was significant difference between the two groups (χ2 = 4.01, P < 0 .05). Although there was no significant difference in the total effective rate between the two groups (χ2 = 0.75, P> 0.05), the treatment group was superior to the control group in controlling seizures, cooling and awakening.