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本文观察了神经性毒剂沙林，梭曼，塔崩和ＶＸ对纯化人脑乙酰胆碱酯酶的抑制作用及肟类药物对这些毒剂抑制的酶的体外重活化作用。结果表明，毒剂抑制人脑乙酰胆碱酯酶的ｐＩ５０为７．９一９．１，毒剂的抑制能力为：梭曼＞沙林≈ＶＸ＞塔崩，脂类药物氯磷定，双解磷，双复磷和ＨＩ一６对沙林和ＶＸ抑制的人脑乙酰胆碱酯酶的重活化作用非常显著，但对梭曼和塔崩抑制的酶则弱，且不同药物对这两种毒剂抑制的乙酰胆碱酯酶的重活化作用也明显不一样，与大鼠脑乙酰胆碱酯酶的实验结果相似。
In this paper, we observed the inhibitory effect of neurotoxic agents sarin, soman, tabun and VX on purified human brain acetylcholinesterase and the in vitro reactivation of enzymes inhibited by oximes against these agents. The results showed that the agent inhibited the pI50 of human brain acetylcholinesterase from 7.9 to 9.1, and the inhibitory potency of the agent was: soman> sarin ≈VX> tabun, lipids chlorophosphorus, bisphospholipids, bis Phosphorus and HI-6 had a significant effect on human brain acetylcholinesterase reactivation by sarin and VX inhibition, but weak enzyme inhibition by soman and tabun and different drugs inhibited acetylcholinesterase Enzyme reactivation is also significantly different, and the rat brain acetylcholinesterase experimental results are similar.