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近年来,国内外越来越多研究表明,心血管疾病的发病与免疫机制参与有关。抗血管紧张素Ⅱ1型受体自身抗体(angiotensinⅡtype 1 receptor-activating antibody,AT1-AA)是一种G蛋白偶联受体(G protein coupled receptor,GPCR)自身抗体,已报道AT1-AA在多种心血管疾病的发生、发展过程中起着重要的作用,本文将主要综述AT1-AA与心血管疾病的研究进展。1 AT1-AA特点血管紧张素Ⅱ1型受体(angiotensinⅡtype 1 receptor,AT1R)属于GPCR超家族,是将胞外信号传导
In recent years, more and more studies at home and abroad show that the pathogenesis of cardiovascular diseases is related to the involvement of immune mechanisms. Anti-angiotensin II type 1 receptor-activating antibody (AT1-AA) is an autoantibody against G protein coupled receptor (GPCR). It has been reported that AT1-AA The occurrence and development of cardiovascular diseases play an important role in the development of this article will be mainly reviewed AT1-AA and cardiovascular disease research. 1 Features of AT1-AA The angiotensin Ⅱ type 1 receptor (AT1R) belongs to the GPCR superfamily and functions as extracellular signal transduction