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目的探讨水飞蓟宾胶囊治疗非酒精性脂肪性肝(NAFLD)患者的临床效果。方法选取2010年1月至2014年6月吉林省人民医院收治的494例NAFLD患者作为研究对象,按随机数字表法将其分为观察组和对照组,各247例。对照组患者给予葡醛内酯片和肌苷片进行治疗,观察组患者口服水飞蓟宾胶囊,比较两组患者的治疗效果和不良反应的发生情况。结果观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应发生率明显低于对照组,差异有统计学意义(χ2=3.324,P<0.05)。结论水飞蓟宾胶囊治疗NAFLD临床效果明显,不良反应少。
Objective To investigate the clinical effect of silybin in treating non-alcoholic fatty liver disease (NAFLD). Methods A total of 494 patients with NAFLD who were admitted to Jilin Provincial People’s Hospital from January 2010 to June 2014 were selected as study subjects and randomly divided into observation group and control group with 247 cases each. Patients in the control group were treated with glucurolactone and inosine tablets. Patients in the observation group were given oral silybin capsules. The therapeutic effect and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that of the control group (χ2 = 3.324, P <0.05). Conclusion Silybin Capsule has obvious clinical effect and few adverse reactions.