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目的采用24h动态监测方法观察硝苯地平控释片在老年高血压患者中的降压效果。方法选择老年高血压病患者60例,每日口服硝苯地平控释片30～60mg,共8周。记录治疗前后24h、昼间及夜间平均收缩压/舒张压和平均收缩压/舒张压负荷;以及平均心率、谷峰比值。结果治疗结束时24h、昼间和夜间平均收缩压/舒张压均较服药前明显下降(P<0.01),分别下降(14.9±4.8)/(8.7±4.7)mmHg、(15.7±5.5)/(8.2±3.5)mmHg、(13.9±4.5)/(8.2±3.8)mmHg;血压负荷值亦明显减少(P<0.01);治疗前后心率无明显变化;谷峰比为收缩压84.2%,舒张压81.6%。结论硝苯地平控释片治疗高血压疗效显著,稳定性好,可持续24h。
Objective To observe the antihypertensive efficacy of nifedipine GITS in elderly hypertensive patients by dynamic monitoring 24h. Methods Sixty elderly patients with essential hypertension were enrolled and were given nifedipine 30 ~ 60mg daily for 8 weeks. The mean systolic blood pressure / diastolic blood pressure and mean systolic blood pressure / diastolic blood pressure were recorded before and after treatment 24h, daytime and nighttime, and the average heart rate, trough-peak ratio. Results The average systolic blood pressure and diastolic blood pressure at the end of treatment were significantly decreased at daytime and at night (P <0.01), decreased by (14.9 ± 4.8) / (8.7 ± 4.7) mmHg and (15.7 ± 5.5) / 8.2 ± 3.5) mmHg, (13.9 ± 4.5) / (8.2 ± 3.8) mmHg respectively. The blood pressure load was also significantly reduced (P <0.01). There was no significant change in heart rate before and after treatment. The peak-to-peak systolic blood pressure was 84.2% and diastolic blood pressure was 81.6 %. Conclusion Nifedipine controlled release tablets for the treatment of hypertension with significant effect, good stability, sustainable 24h.