本文通过文献复习和调查论文原著的方式对近２０年间国内公开出版的２０９６篇临床治疗试验论著中流行病学方法的应用状况进行了回顾和总结，结果表明：对照、随机、盲法应用率分别为５３％、１４％和５％；同期随机对照（含半随机）所占比重为３５．２％；对照组设置合理的占４８％；病例精选不足的占５４％。 This paper reviews and summarizes the application status of epidemiological methods in 2,096 clinical trial published in domestic in the past 20 years through literature review and original investigation of the thesis. The results show that the application rates of control, randomization and blindness are respectively Were 53%, 14% and 5% respectively. In the same period, the proportion of randomized control (including semi-random) was 35.2%, that of control group was 48%, and that of poorly selected patients was 54%.