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目的 探讨人类白细胞分化抗原 (HL A ) - DR4等位基因与福建籍汉族类风湿关节炎 (RA)易感性及病情和预后估计的意义。方法 用聚合酶链反应 -序列特性引物基因扩增法 (PCR- SSP)对 98例 RA和 10 0例正常人进行 HL A- DR4基因型鉴定 ,并作病程、红细胞沉降率 (ESR)、 C反应蛋白 (CRP)、类风湿因子 (RF)、补体 3(C3)、补体 4 (C4 )、X线分期的比较分析。结果 RA患者 HL A- DR4等位基因频率显著高于正常组 (5 8.1%对 2 1% ) ,DR4阳性组 RA较阴性组病程长 ,ESR、CRP及 RF值升高 ,C3、C4降低 ,易发生早期的骨质侵蚀。结论 福建籍汉族人群中 RA和 HL A- DR4显著相关 ,HL A- DR4可作为估计 RA病情及预后的指标。
Objective To investigate the susceptibility of human leukocyte differentiation antigen (HLA-DR4) to rheumatoid arthritis (RA) and its prognosis in Fujian Han nationality. Methods The HLA-DR4 genotypes of 98 cases of RA and 100 normal controls were identified by polymerase chain reaction-sequence specific primer amplification (PCR-SSP). The course of disease, erythrocyte sedimentation rate (ESR), C Reactive protein (CRP), rheumatoid factor (RF), complement 3 (C3), complement 4 (C4), X-ray staging comparative analysis. Results The frequency of HLA-DR4 alleles in RA patients was significantly higher than that in controls (8.1% vs 21.1%). The DR4-positive RA patients had longer duration of disease, higher ESR, CRP and RF, lower C3 and C4, Early prone to bone erosion. Conclusions There is a significant correlation between RA and HL A-DR4 in Han nationality in Fujian Province. HL-DR4 may be used as an index to evaluate the prognosis and prognosis of RA.