配体通过靶向特殊基因,进而调节该基因所参与的生物学功能一直是生物无机化学领域十分活跃的研究课题.当前,金属配合物对DNA的结构识别以及功能调控引起了人们的高度重视,越来越多的研究表明,金属配合物能够有效地识别DNA的二级结构并影响其生物学功能.最近研究发现,一些具有纳米尺度的金属超分子配合物能够特异性识别DNA并表现出特殊的生物学效应.本文总结了纳米尺度金属超分子配合物对不同DNA二级结构的选择性识别及调控等方面的研究进展. Ligand by targeting specific genes, and then regulate the biological functions involved in the gene has been a very active research topic in the field of bio-inorganic chemistry.Currently, the metal complexes on DNA structure recognition and functional regulation has attracted people’s attention, More and more studies have shown that metal complexes can effectively identify the secondary structure of DNA and affect its biological function.Recent studies have found that some of the nano-scale metal supramolecular complexes can specifically recognize DNA and show special The biological effects of nanoscale metal supramolecular complexes on the selective recognition and regulation of DNA secondary structures were summarized.