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经一次气管灌注不同剂量可溶性六价铬酸钠（Ｎａ２ＣｒＯ４）后第２天和一次灌注０．９８ｍｇ·ｋｇ－１Ｎａ２ＣｒＯ４后不同时间，观察了ＳＤ大鼠支气管肺泡灌洗液（ＢＡＬＦ）和血液生化改变的剂量效应与时间过程。结果表明，Ｎａ２ＣｒＯ４的无效应剂量与阈剂量分别为０．００８和０．０４ｍｇ·ｋｇ－１，染毒剂量≥０．２０ｍｇ·ｋｇ－１时，ＢＡＬＦ中绝大多数生化参数呈现显著的剂量依赖性增加；严重中毒剂量（≥０．９８ｍｇ·ｋｇ－１）可引起ＢＡＬＦ和血液中几乎所有测试参数的显著增加，这种现象约持续一周，至少需要４周才能恢复正常。分析本次研究结果，可得出以下结论：≥０．９８ｍｇ·ｋｇ－１的Ｎａ２ＣｒＯ４可导致包括肺内细胞损伤、弥漫性肺泡炎和肺水肿在内的急性肺损伤；Ｎ－乙酰－β－Ｄ－氨基葡糖苷酶（ＮＡＧ）、溶菌酶（ＬＹＳ）、碱性磷酸酶（ＡＬＰ）、白蛋白（ＡＬｂ）和血管紧张素转换酶（ＡＣＥ），可能是评价接触较低剂量Ｎａ２ＣｒＯ４（＜０．９８ｍｇ·ｋｇ－１）后所致急性肺损伤的最有价值的早期敏感指标
The bronchoalveolar lavage fluid (BALF) and blood biochemical changes in SD rats were observed at different times after a single tracheal injection of Na2CrO4 at different doses and 0.98 mg · kg-1Na2CrO4 at a time. The dose effect and time course. The results showed that the effective dose of Na2CrO4 and the threshold dose were 0.008 and 0.04 mg · kg-1, respectively. Most of the biochemical parameters in BALF were significantly dose-dependent when the dose was ≥ 0.20 mg · kg-1 ; Severe poisoning dose (≥0.98mg · kg-1) caused a significant increase of almost all test parameters in BALF and blood, which lasted for about one week and required at least 4 weeks to return to normal. Analysis of the results of this study leads to the following conclusion: Na2CrO4> = 0.98 mg kg "1 can cause acute lung injury including intrapulmonary cell injury, diffuse alveolitis and pulmonary edema; N-acetyl- D-glucosaminidase (NAG), lysozyme (LYS), alkaline phosphatase (ALP), albumin (ALb) and angiotensin converting enzyme (ACE) may be evaluated for exposure to lower doses of Na2CrO4 (<0 .98mg · kg-1) acute lung injury caused by the most valuable early sensitive indicators