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Objective:To study the effect of maternal BDE-209 (brominated Diphenyl Ethers-209) exposure on the expression of microtubule-associated protein-1 b ( map-1 b) and S100 in rats hippocampus of the offspring by RT-PCR. Methods:Peanut oil suspensions of comand lactation in experimental group. The control group was administered only with the same capacity of peanut oil at the same time. The expression of MAP-1B in the hippocampus of the off.springs rats were tested when the pups were newborn,7days, 14 days , 21days and 45days old respectively by means of RT-PCR. Result: MAP-1B protein showed a statistically significantly lower concentration in the groups 14 days, 21days,45days than that of the control groups. The expression of S-100 in the group which received with deca-BDE by RT-PCR showed higher than that of control groups. But only the 45days groups had significant difference of expression of MAP-1B protein compared with the control groups( P ＜ 0.05 ). Conclusions: Maternal BDE-209 exposure during the period of pregnancy will diminish the expression of map-1 b protein in hippoeampus of offsprings rats.