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1978年9月至1984年3月共5年7个月中作者观察鼻、鼻窦恶性黑素瘤8例,其中男3例,女5例。平均年龄62.5岁。按UICC第3版皮肤恶性黑素瘤分类为la期2例,lb期2例、Ⅱ期2例,Ⅵ期2例。采用系统综合治疗。卡介苗一次量80mg,其中20mg散剂口服,另60mg装入肠溶胶囊口服,目的是使卡介苗菌直达与口、咽、食管等部消化道有关的淋巴系统。根据免疫学参数变动,每2至4周给药一次。总量5000～6000mg。近期病变进展者可经血浆交换导入卡介苗。化疗采用DTIC(dimethyl triazeno imidazole carboxamide,黑素瘤抑制剂),原则上需入院
From September 1978 to March 1984, a total of 8 cases of malignant melanoma of the nose and sinuses were observed in 5 years and 7 months, including 3 males and 5 females. The average age is 62.5 years old. According to the UICC 3rd edition, the malignant melanoma of the skin was classified as la stage in 2 cases, lb stage in 2 cases, II stage in 2 cases, and VI stage in 2 cases. Systematic comprehensive treatment. Bacillus Calmette Guerin once the amount of 80mg, of which 20mg powder oral, and the other 60mg loaded enteric-coated capsules orally, the purpose is to make Bacillus Calmette flu vaccine directly to the mouth, pharynx, esophagus and other digestive tract-related lymphatic system. According to changes in immunological parameters, dosing occurs every 2 to 4 weeks. Total 5000-6000mg. Progressive lesions can be introduced into the BCG vaccine via plasma exchange. Chemotherapy with DTIC (dimethyl triazeno imidazole carboxamide, melanoma inhibitor), in principle, need to be admitted