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目的探讨多层CT肺灌注成像技术在肺癌TNM分期中的临床应用价值。方法收集行MSCT灌注成像的肺癌患者20例,均经手术病理证实,其中鳞癌7例,腺癌11例,小细胞肺癌2例。使用GELight-speedPlus16层CT机行肺CT灌注扫描。应用Perfusion2软件进行灌注成像分析。结果20例肺癌病例的CT灌注图像均比较满意。CT灌注参数对于肺癌的T分期有一定帮助。<3cm的肺癌(T1)血管表面通透性(PS值)明显低于>3cm(T2)的PS值,有统计学意义。胸膜受累的肺癌较胸膜未受累的肺癌血流量(BF)、血容量(BV)及PS值均增加及平均通过时间(MTT)加快;有淋巴结转移的肺癌较无转移的BV增加和MTT加快,而BF和PS相差不大,但是,均缺乏统计学差异。有无远处转移对灌注参数影响不大。结论MSCT灌注成像对于肺癌的T分期有一定帮助。
Objective To investigate the clinical value of multi-slice CT lung perfusion imaging in the TNM staging of lung cancer. Methods Twenty patients with lung cancer who underwent MSCT perfusion imaging were enrolled. All of them were confirmed by surgery and pathology. There were 7 cases of squamous cell carcinoma, 11 cases of adenocarcinoma and 2 cases of small cell lung cancer. Use GELight-speedPlus16-slice CT lung CT perfusion scan. Perfusion2 software perfusion imaging analysis. Results CT perfusion images of 20 cases of lung cancer were satisfactory. CT perfusion parameters for the T stage of lung cancer have some help. The blood vessel surface permeability (PS) of lung cancer (T1) <3cm was significantly lower than PS> 3cm (T2), with statistical significance. Pleural involvement of lung cancer than pleural uninfilcted lung cancer blood flow (BF), blood volume (BV) and PS values were increased and the average transit time (MTT) accelerated; with lymph node metastasis of lung cancer than without BV increased and MTT accelerated, However, BF and PS are similar or not, however, there is no statistical difference. Whether or not distant metastasis has little effect on perfusion parameters. Conclusion MSCT perfusion imaging is helpful for the T stage of lung cancer.