This work makes the quantitative constrain on tectonizations of the Gangdese block, south Qinghai-Tibetan Plateau. Apatite fission track (AFT) dating analyses of 15 samples collected across the Gangdese block show that the Gangdese block went through two periods of tectonizations, during ~37.2 - 18.5 Ma and 18.5 - 8.0 Ma in the south Gangdese block, and during ~47.6 - 5.3 Ma and 5.3 - 0 Ma in the middle Gangdese block. Different upliftings did not take place in the first period and rapid uplifting occurred in the late period. Meantime, there are some differences between the south and middle Gangdese block. Their uplifting rate is 180 m/Ma and 70 m/Ma respectively. The rapid uplifting time in the middle Gangdese block lagged behind the time in the south Gangdese block. It is Chala-Jiacuo-Riduo fault zone that is similar to the Yarlung Zangbo fault zone in control of the tectonization.