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目的：探讨老年急性缺血性脑卒中患者血浆超氧化物歧化酶（SOD）水平与其出院结局不良的关系。方法：采用回顾性队列研究的方法，连续性纳入急性缺血性脑卒中住院患者1682例，收集人口统计学、生活方式和实验室检查结果等资料。结局不良定义为患者出院时改良的Rankin 评分（MRS）≥3分，结局良好MRS＜3分。采用非条件Logistic回归分析入院时血浆SOD水平与出院结局不良的关系。结果：结局良好组与结局不良组入院时SOD水平差异无统计学意义（P >0.05）。用三分位数法将入院时SOD 水平分为3组，>200mmol/L,100-200mmol/L,200mmol/L组相比，<100mmol/L组发生出院结局不良的OR 值（95% CI）为1.326(1.018-1.763)。经多因素调整后，同样<100mmol/L组增加了急性缺血性脑卒中患者发生出院结局不良的风险，OR 值（95% CI）为1.467(1.019-2.075),并且随着SOD 水平的降低发生出院结局不良的风险也在增加（趋势性P＜0.05）。结论：入院时血浆SOD 水平降低可增加急性缺血性脑卒中患者出院结局不良发生的风险，并存在剂量-反应关系，是脑血管病的危险因素。“,”Objective:To explore the relationship between SOD level adverse clinical outcome among patients with acute ischemic stroke. Methods:A non-concueernt cohort study was performed,continuity incorporated may 31,2009 to may 31,2013 inpatients with acute ischemic stroke inpatients in Affliated Hospital of Chengde Medical Colege Department of internal medicine,colecting demographic and laboratory data.To accord with the stroke scale score criteria of the study hospital (Modified Rankin,s scale,MRS) (MRS200mmol/L,200-100mmol/L,<100mmol/L). Logistic regression analysis was used. Results:After SOD quintiles, the proportion of poor outcome patients in each group were 28.47%,33.51%, 37.40%.After single factor analysis, compared with the first group ,the OR (95% CI) of the third group was 1.326 (1.018-1.763).