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目的探讨一种新的末梢动脉栓塞剂,减少栓塞盲区。方法将粉碎灭菌的自体毛发颗粒混入抗癌药液及水性造影剂,经导管灌入靶动脉,对38例老年中晚期肝癌病人进行栓塞化疗结果影像学证实发丝样肿瘤血管及肿瘤染色消失,肿瘤直径缩小50%以上者73.7%(28/38),缩小25%~50%者21.0%(8/38),肿瘤无变化或缩小25%以下者5.3%(2/38)。AFP下降者81.6%(31/38)。6、12、18、24个月生存率分别为100%、83.3%、75%、66.7%。临床症状及肝功能均有改善。所有病人均未发生异位误栓及排异反应,栓塞后综合征轻微。结论自体毛发颗粒作为永久性末梢动脉栓塞剂治疗老年肝癌是安全有效的
Objective To explore a new peripheral arterial embolization agent and reduce the blind area of embolism. Methods Pulverized and sterilized autologous hair particles were mixed with anticancer drug solution and aqueous contrast agent, and then injected into the target artery via catheter. 38 cases of advanced middle-advanced liver cancer patients were treated with embolization. Radiological results confirmed the disappearance of vascular and tumor staining of hair-like tumors. 57% of the tumors were reduced by 73.7% (28/38), 25% to 50% were reduced by 21.0% (8/38), and tumors were unchanged or reduced by 25% or less (5.3%). /38). The AFP decline was 81.6% (31/38). The 6, 12, 18, and 24 months survival rates were 100%, 83.3%, 75%, and 66.7%, respectively. Clinical symptoms and liver function improved. All patients did not experience ectopic thrombolysis and rejection. The syndrome was mild after embolization. Conclusion Autologous hair granules as a permanent peripheral arterial embolization agent for the treatment of elderly liver cancer is safe and effective