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目的:总结多发性骨髓瘤(MM)患者社区感染和院内感染的特点,了解2类感染间的差异,以期对2类感染在抗生素的选择上有所帮助。方法:回顾性分析近5年来我院多发性骨髓瘤(MM)患者社区感染和院内感染情况。结果:MM患者47例,发生感染20例,占42.55%,其中院内感染16例(80%),痰培养铜绿假单胞菌ESBLs(+)1例、肠球菌1例、白色念珠菌1例、光滑念珠菌1例;中段尿培养大肠埃希氏菌ESBLs(+)1例、类星形念珠菌1例;血培养肺炎链球菌1例;社区感染4例(20%);肺结核并铜绿假单胞菌ESBLs(-)1例、铜绿假单胞菌ESBLs(-)1例、白色念珠菌1例。结论:我院近5年MM患者的感染以院内感染为主,细菌与真菌约各占一半,细菌以ESBLs阳性为主;社区感染中细菌、真菌、结核均可出现,细菌感染ESBLs为阴性。
OBJECTIVE: To summarize the characteristics of community and nosocomial infections in patients with multiple myeloma (MM) and to understand the differences between the two types of infections in order to help class 2 infections in the selection of antibiotics. Methods: The community infection and nosocomial infection of patients with multiple myeloma (MM) in our hospital in recent 5 years were analyzed retrospectively. Results: Among the 47 patients with MM, 20 cases were found (42.55%), including 16 cases of nosocomial infection (80%), 1 case of sputum culture of Pseudomonas aeruginosa ESBLs (+), 1 case of enterococci and 1 case of Candida albicans , One case of Candida glabrata; one case of Escherichia coli ESBLs (+) in urine culture in middle stage, one case of Candida albicans; one case of Streptococcus pneumoniae in blood culture; four cases of community infection (20%); 1 case of Pseudomonas ESBLs (-), 1 case of Pseudomonas aeruginosa ESBLs (-), 1 case of Candida albicans. CONCLUSIONS: The infection of MM patients in our hospital was mainly nosocomial infection in the recent 5 years, with bacteria and fungi accounting for about half of each. The bacteria were mainly ESBLs-positive. Bacteria, fungi and tuberculosis could be found in community-acquired infections. The bacterial infections were negative for ESBLs.