目的测定胃液中的胆红素浓度以评价二甲基硅油对胆汁反流的疗效．方法慢性胃炎患者６５例，其中伴胆汁反流４５例，进一步分成２组：治疗组（３０例）在测定前服二甲基硅油＋硫糖铝；对照组（１５例）单服硫糖铝．用胆红素氧化酶法测定胆红素浓度．结果无胆汁反流的２０名患者中，胃液中胆红素浓度分别检测１５例为０，５例为０４μｍｏｌ／Ｌ～０８μｍｏｌ／Ｌ；治疗组在服二甲基硅油前后均值分别为（１６０±１２０）μｍｏｌ／Ｌ和（６６±４９）μｍｏｌ／Ｌ（Ｐ＜００１），而对照组则分别为（１４６±１２３）μｍｏｌ／Ｌ和（１５９±１９８）μｍｏｌ／Ｌ（Ｐ＞００５）；胆红素浓度减少３０％以上者治疗组中占８００％，对照组中占２６７％，两组间有高度显著差异（χ２＝１２１００８．Ｐ＜００１）．结论测定胃液中胆红素有助于判断胆汁反流，并肯定二甲基硅油可减少胆汁反流，从而减轻胆汁反流性胃炎． Objective To determine the concentration of bilirubin in gastric juice to evaluate the efficacy of dimethyl silicone oil on bile reflux. Methods 65 patients with chronic gastritis, including 45 cases with bile reflux, were further divided into two groups: the treatment group (30 cases) before taking the determination of simethicone + sucralfate; control group (15 cases) . Determination of bilirubin concentration with bilirubin oxidase method. Results In the 20 patients without bile reflux, the bilirubin concentrations in gastric juice were detected in 0 and 5 cases from 04μmol / L to 08μmol / L, respectively. (160 ± 120) μmol / L and (6.6 ± 4.9) μmol / L (P <001), while those in the control group were (146 ± 123) μmol / L and (159 ± 198) μmol / L, respectively (P> 005). The bilirubin concentration decreased by 30% or more in the treatment group, accounting for 800% in the treatment group and 267% in the control group, There was a highly significant difference between the two groups (χ2 = 121008.P <001). Conclusion The determination of bilirubin in gastric juice is helpful in judging the bile reflux, and it is confirmed that dimethyl silicone oil can reduce bile reflux and relieve bile reflux gastritis.