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目的研究血清血管内皮细胞生长因子(VEGF)和C反应蛋白(CRP)的表达,在结直肠癌患者不同病理阶段的临床意义及对CRC的诊断价值。方法对79例结直肠癌患者和35例健康志愿者血清检测VEGF和CRP表达浓度。结果 79例VEGF和CRP的表达水平在结直肠癌患者体内高于健康对照。VEGF和CRP的表达在不同年龄和性别的结直肠癌患者中差异无统计学意义,VEGF的表达随肿瘤Dukes分期、分化程度和肿瘤大小逐渐升高,CRP的血清浓度和结直肠癌的Dukes分期、分化程度和肿瘤大小无显著相关性。ROC分析显示VEGF和CRP的AUC分别为0.710和0.702,对结直肠癌的检测灵敏度分别为62.5%和68.7%,特异性分别为75.0%和65.0%。联合检测中,Logistic分析的AUC为0.735,系列法和平行法分析灵敏度和特异性最高达到88.35%和91.25%。结论 VEGF和CRP表达水平在结直肠癌患者体内升高,VEGF和CRP表达对于结直肠癌的诊断具有重要的价值,VEGF可能参与结直肠癌疾病的发生和发展。
Objective To study the clinical significance of the expression of serum vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) in different pathological stages of patients with colorectal cancer and the diagnostic value of CRC. Methods Serum levels of VEGF and CRP were measured in 79 patients with colorectal cancer and 35 healthy volunteers. Results The expression levels of VEGF and CRP in 79 patients were higher than those in healthy controls in patients with colorectal cancer. VEGF and CRP expression in colorectal cancer patients of different ages and genders was no significant difference, VEGF expression with tumor Dukes stage, degree of differentiation and tumor size gradually increased, CRP serum concentration and colorectal cancer Dukes stage There was no significant correlation between the degree of differentiation and tumor size. ROC analysis showed that the AUC of VEGF and CRP were 0.710 and 0.702, respectively. The detection sensitivity of colorectal cancer were 62.5% and 68.7%, and the specificity was 75.0% and 65.0% respectively. In the combined test, the AUC of Logistic analysis was 0.735, and the sensitivity and specificity of series and parallel methods were 88.35% and 91.25% respectively. Conclusions The expression of VEGF and CRP is elevated in colorectal cancer patients. The expression of VEGF and CRP is of great value in the diagnosis of colorectal cancer. VEGF may be involved in the occurrence and development of colorectal cancer.