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目的介绍血管内皮生长因子C(VEGF-C)及受体在淋巴管形成过程中的作用机理及其与胃癌淋巴转移关系研究的最新进展。方法通过复习国内、外文献,对VEGF-C及其受体在胃癌组织中的表达、在胃癌淋巴结转移中的作用及其在胃癌治疗上的应用前景进行综述和分析。结果 VEGF-C及其受体与胃癌淋巴管形成及淋巴转移关系密切,VEGF-C高表达可认为是淋巴结转移的早期事件,并可作为预测发生淋巴结微转移的独立因素。通过抑制胃癌细胞分泌VEGF-C或阻断VEGF-C与受体VEGFR-3结合,可以抑制胃癌新生淋巴管形成、癌细胞浸润及远处播散,从而降低死亡率,改善患者预后。结论 VEGF-C及其受体能促进了胃癌淋巴管生成及淋巴转移,针对VEGF-C及其受体的治疗方法有望成为胃癌治疗的一个新手段。
Objective To introduce the mechanism of vascular endothelial growth factor C (VEGF-C) and its receptors in the process of lymphangiogenesis and its recent progress in lymphatic metastasis of gastric cancer. Methods By reviewing the literature both at home and abroad, the expression of VEGF-C and its receptor in gastric cancer tissue and its role in lymph node metastasis of gastric cancer and its application in the treatment of gastric cancer were reviewed and analyzed. Results VEGF-C and its receptor were closely related to lymphangiogenesis and lymphatic metastasis in gastric cancer. High expression of VEGF-C could be regarded as an early event of lymph node metastasis and could be used as an independent predictor of lymph node micrometastasis. Inhibition of gastric cancer cells secreting VEGF-C or blocking the VEGF-C and receptor VEGFR-3 binding, can inhibit gastric neoplasia lymphangiogenesis, cancer cell infiltration and distant dissemination, thereby reducing mortality and improve patient prognosis. Conclusion VEGF-C and its receptor can promote lymphangiogenesis and lymphatic metastasis in gastric cancer. The treatment of VEGF-C and its receptor is expected to be a new treatment for gastric cancer.