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目的探讨长期服用小剂量肠溶阿司匹林对老年高血压患者血尿酸的影响。方法用随机双盲法将老年轻、中度高血压 10 5例分为阿司匹林治疗组和对照组。治疗组给肠溶阿司匹林 40 mg/ d,加尼莫地平、开搏通降压治疗 :对照组单用尼莫地平 40 mg/ d、开搏通37.5～ 75 mg/ d,不用肠溶阿司匹林 ,持续治疗 1年。记录治疗前及治疗第 6、12月的血压、心率及血尿酸变化。结果阿司匹林治疗组血尿酸较对照组显著升高 [由 ( 0 .43± 0 .0 7) mmol/ L至 ( 0 .5 6± 0 .0 3) mmol/ L ] ,两组间第 6、12月血尿酸差值比较 P<0 .0 1,有显著性差异。两组血压及其余生化指标无显著差异。结论长期小剂量阿司匹林治疗可引起高尿酸血症 ,应采取措施加以预防
Objective To investigate the effect of long-term administration of low-dose enteric-coated aspirin on serum uric acid in elderly hypertensive patients. Methods A randomized, double-blind method was used to divide 105 cases of elderly mild to moderate hypertension into aspirin group and control group. In the treatment group, enteric-coated aspirin 40 mg / d, ganamodipine and captopril were taken. In the control group, nimodipine 40 mg / d and captopril 37.5-75 mg / d were given alone. In the control group, no aspirin, Continued treatment for 1 year. Record before treatment and treatment of 6, 12 months of blood pressure, heart rate and serum uric acid changes. Results Serum uric acid in aspirin group was significantly higher than that in control group [(0 .43 ± 0. 0 7) mmol / L to (0. 56 ± 0. 0 3) mmol / L] December serum uric acid difference compared P <0. 01, there was a significant difference. No significant difference in blood pressure and other biochemical parameters between the two groups. Conclusion Long-term low-dose aspirin treatment can cause hyperuricemia, and measures should be taken to prevent it