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目的：为探讨肺癌组织中P53和P21癌基因蛋白的表达及其临床意义。方法：应用免疫组化方法（S－P法）检测69例肺癌组织标本中P53和P21癌基因蛋白表达，结果采用卡方检验。结果：P53和P21在肺癌组织中的阳性表达率分别为49.3％、68．1％；肺癌癌旁支气管粘膜和腺体中的阳性表达率分别为0和17.6％，与肿瘤区相比较差异均非常显著（P＜0．01）。P53蛋白表达与肺癌病人术后生存期有一定关系，P53阳性率越高，其存活期越短。P21蛋白表达肺腺癌高于肺鳞癌（P＞0．05）。P53和P21蛋白表达与肺癌病人性别、年龄、肿瘤分期和分化程度无关。结论：肺癌患者术后预后不良与P53蛋白积累有关，P53蛋白蓄积是判定肺癌预后的指标之一，ras基因突变是肺癌发生的早期事件，与肺腺癌发生更有密切关系。
Objective: To investigate the expression and clinical significance of P53 and P21 oncogene proteins in lung cancer. METHODS: Immunohistochemical method (S-P method) was used to detect the expression of P53 and P21 oncogene proteins in 69 lung cancer specimens. The results were analyzed by chi-square test. Results: The positive expression rates of P53 and P21 in lung cancer tissues were 49.3% and 68.1% respectively. The positive expression rates of lung cancer adjacent to lung cancer were 0 and 17.6%, respectively. Very significant (P<0.01). The expression of P53 protein has a certain relationship with the survival time of lung cancer patients. The higher the positive rate of P53, the shorter the survival time. P21 protein expression was higher in lung adenocarcinoma than in lung squamous cell carcinoma (P>0.05). The expression of P53 and P21 protein was not related to gender, age, tumor stage and differentiation of lung cancer patients. Conclusion: The postoperative prognosis of patients with lung cancer is related to the accumulation of P53 protein. The accumulation of P53 protein is one of the indicators of the prognosis of lung cancer. The ras gene mutation is an early event of lung cancer and has a close relationship with the occurrence of lung adenocarcinoma.