肾脏调节尿钠排泄的作用,数十年来一直受到生理学家的重观。由于钠的过滤负荷与其排泄量有明显相关,所以肾小管钠重吸收的轻微改变对钠平衡有显著作用。当分离醛固酮时,持乐观态度的人假定肾上腺皮质理盐激素活性的变化可充分地维持尿钠排泄处一个理想水平,肾上腺皮质理盐激素可经肾小球过滤的改变而得以平衡,在需要的水平上足以维持钠的排泄。de Wardener组的实验结果表明情况并不这样,因为在这些影响因素被排除后,钠负荷仍可产生促尿钠排泄作用,“第三因子”一词迄今仍颇为流行,直到对排钠起作用的多 The role of the kidneys in regulating urinary sodium excretion has been rethought by physiologists for decades. Because sodium filtration load is significantly correlated with its excretion, a slight change in renal tubular sodium reabsorption has a significant effect on sodium balance. When isolating aldosterone, those who are optimistic assume that changes in the activity of the adrenal cortical salt can adequately maintain the urinary sodium excretion at an ideal level, and adrenal cortical salt hormone can be balanced by changes in glomerular filtration, where needed Level enough to maintain sodium excretion. The experimental results of the de Wardener group indicate that this is not the case, as natriuresses can still produce natriuresque excretion after these factors have been ruled out, and the term “third factor” has hitherto been prevalent until sodium The role of more