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目的 探讨氨基甙类抗生素—阿贝卡星 (arbekacin ,ABK) ,阿司霉素 (astromicin ,ASTM) ,异帕咪星 (isepamicin ,ISP)和奈替咪星 (netilmicin ,NTL)在家兔的膈肌 ,前胫骨肌和比目鱼肌的神经肌肉抑制作用。方法 将 2 4只家兔平均分成 4组 ,戊巴比妥静脉麻醉下分别游离膈神经 -膈肌 ,胫神经 -前胫骨肌和腓总神经 -比目鱼肌 ,然后在膈肌表面和肢体肌远端肌腱固定连接肌张力换能测定装置以及在上述神经固定神经刺激电极 ,给予频率为 0 1Hz ,持续 0 1ms ,间隔 10s的超强电刺激。采用累积剂量给药法分别静脉注射以上被验 4种抗生素 ,记录刺激神经所诱发的肌肉等张颤搐强度 ,评价抗生素在 3种肌群不同神经肌肉抑制作用。结果 4种抗生素在以上 3种骨骼肌肌群均表现不同程度的抑制作用 ,在初期剂量给药时 ,膈肌对药物的敏感性较明显 ,比目鱼肌表现相对最弱。抗生素作用于这 3种肌群的ED50 值大小顺序为比目鱼肌 >前胫骨肌 >膈肌和ED95值大小顺序为比目鱼肌 >膈肌 >前胫骨肌。抗生素在前胫骨肌和比目鱼肌的ED50 值约分别为膈肌的 1 5和 2 7倍。 4种抗生素间神经肌肉抑制作用强度顺序为NTL >ABK >ASTM >ISP。这些抗生素引起的神经肌肉抑制作用可以被新斯的明和钙剂所拮抗。结论 4种氨基甙类抗生素在膈肌相?
Objective To investigate the effects of aminoglycoside antibiotics such as arbekacin (ABK), astromicin (ASTM), isepamicin (ISP) and netilmicin (NTL) Diaphragm, anterior tibial and soleus muscle neuromuscular inhibition. Methods 24 rabbits were equally divided into 4 groups. The rats were randomly divided into 5 groups: phrenic nerves-diaphragmatic muscle, tibial nerve-anterior tibial muscle and peroneal nerve-soleus muscle under pentobarbital intravenous anesthesia. Fixed connection muscle tone transducer measuring device and in the nerve fixed nerve stimulation electrode, giving a frequency of 0 1Hz, sustained 0 1ms, 10s interval super-electrical stimulation. The above four antibiotics were intravenously injected by the cumulative dose administration method, the tonic strength of the muscle induced by the nerve stimulation was recorded, and the different neuromuscular inhibitory effects of the antibiotics on the three muscle groups were evaluated. Results The results showed that the four kinds of antibiotics showed different degrees of inhibition in the muscle of the above three kinds of skeletal muscles. When the initial dose was administered, the sensitivity of the diaphragm to the drug was obvious, and the soleus showed the weakest. The order of the ED50 values of antibiotics on these three kinds of muscles was orderly soleus> anterior tibialis muscle> diaphragm and ED95 values in the order of soleus> diaphragmatic> anterior tibial muscle. The ED50 values of antibiotics in the anterior tibial and soleus muscles were about 15 and 27 times that of the diaphragm, respectively. The order of intensity of neuromuscular inhibition among the four antibiotics was NTL> ABK> ASTM> ISP. The neuromuscular inhibition caused by these antibiotics can be antagonized by neostigmine and calcium. Conclusion 4 kinds of aminoglycoside antibiotics in the diaphragm phase?