棉酚所致低血钾症,严重影响其临床应用,引起这种低血钾症的直接原因为肾性失钾。目前,临床除补充钾盐外,尚未见到其它有效的防治方法。保钾利尿药氨苯喋啶可减少肾小管远端 Na~+重吸收,抑制K~+—Na~+交换,从而减少 K~+从肾脏排出,该药可防治其它原因引起的肾性失钾。本研究观察氨苯喋啶是否影响棉酚的抗生育作用和毒性,为临床合用棉酚与保钾利尿药提供依据。 Gossypol-induced hypokalemia seriously affects its clinical application. The direct cause of hypokalemia is renal potassium loss. At present, in addition to potassium supplements, no other effective control methods have yet been seen. The potassium-sparing diuretic ampicillin reduces Na+ reabsorption in the distal tubule and inhibits K~+-Na~+ exchange, thereby reducing K~+ excretion from the kidney. This drug can prevent renal failure caused by other causes. Potassium. In this study, it was observed whether triamterene affects the anti-fertility and toxicity of gossypol, providing evidence for the clinical use of gossypol and potassium-sparing diuretics.