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目的:通过对比研究的方式探究糖皮质激素吸入治疗疗程长短对哮喘患儿肺功能的影响,以期达到最佳疗效。方法:随机抽取处于发作期的哮喘儿童80例,随机均分为A、B两组,各40例,两组患者均采用糖皮质激素干粉剂吸入治疗,A组疗程为1年,B组疗程为2年。治疗前及治疗后测定所有患者的肺功能,包括用力肺活量(FVC)、1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)、最大呼气流量(MEF)值,多次测量计算平均值,计算测量值占预计值百分比。结果:治疗后两组患者各指标均有显著改善,差异有统计学意义(P<0.05);组间对比,B组患者治疗后FVC、FEV1、PEF、MEF均高于A组,其中FVC、FEV1差异无统计学意义(P>0.05),PEF、MEF差异有统计学意义(P<0.05)。结论:糖皮质激素吸入治疗可以有效控制哮喘患儿症状,长期坚持应用小剂量糖皮质激素吸入治疗为最佳,至两年以上更为有效。
Objective: To explore the effect of glucocorticoid inhalation therapy on lung function in children with asthma through comparative study, in order to achieve the best effect. Methods: Eighty children with asthma at random were randomly divided into A and B groups, 40 cases in each. Both groups were treated with glucocorticoid powder inhalation. The course of treatment in group A was 1 year. The treatment of group B For 2 years. Pulmonary function, including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), maximum expiratory flow (MEF), and multiple measurements of all patients were measured before and after treatment Average, calculate the measured value as a percentage of the expected value. Results: After treatment, the indexes of both groups were significantly improved, the difference was statistically significant (P <0.05); between groups, FVC, FEV1, PEF, MEF after treatment in group B were higher than those in group A, There was no significant difference in FEV1 between the two groups (P> 0.05). There was significant difference between PEF and MEF (P <0.05). Conclusion: Glucocorticoid inhalation therapy can effectively control the symptoms of asthmatic children. It is most effective to persistently apply low-dose glucocorticoid inhalation for more than two years.