胰岛素不足和胰岛素抵抗在Ⅱ型糖尿病(NID-DM)中的发病作用仍有争论。显然,如果胰岛素不足在糖尿病糖耐量中起重要作用,那么可以想象所有NIDDM患者的血浆胰岛素反应均应降低。血浆胰岛素的特异性测定较困难,这是因为从胰岛素原生成胰岛素的过程中尚有其它分子存在(包括C一肽,完整的和部分修饰的胰岛素原)。就作者所知,目前尚没有一种胰岛素测定方法在胰岛素和部分修饰的胰岛素原中间产物存在的情况下能特异性 Insulin deficiency and insulin resistance in type 2 diabetes (NID-DM) in the pathogenesis is still controversial. Obviously, if insulin deficiency plays an important role in diabetic glucose tolerance, then it is conceivable that all patients with NIDDM have a reduced plasma insulin response. The specific determination of plasma insulin is more difficult because of the presence of other molecules (including C-peptide, intact and partially modified proinsulin) from the proinsulin production. To the authors’ knowledge, there is currently no single method for determining insulin that is specific for the presence of insulin and a partially modified proinsulin intermediate