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目的 探讨大肠癌术前测定血清CA242的临床意义。方法 采用放射免疫分析测定165例大肠癌患者术前血清中CA242的浓度。结果 本组165例大肠癌中有82例CA242表达阳性(49.7%),CA242阳性表达与患者性别、年龄、肿瘤部位及大小差异无显著性(P>0.05)。肿瘤发生淋巴结转移或肿瘤细胞分化程度较差的(低分化、未分化)血清CA242阳性率显著高于无淋巴结转移或细胞分化程度较好的(高、中分化)(P<0.05)。晚期肿瘤的CA242阳性率亦明显高于早期者(P<0.05)。结论 术前测定CA242有助于判断大肠癌有无淋巴结转移及肿瘤进展和分期。
Objective To investigate the clinical significance of preoperative determination of serum CA242 in colorectal cancer. Methods Radioimmunoassay was used to determine the concentration of CA242 in preoperative serum of 165 patients with colorectal cancer. Results 82 cases of colorectal cancer 165 cases of CA242 positive expression (49.7%), CA242 positive expression and the patient sex, age, tumor location and size was no significant difference (P> 0.05). The positive rate of CA242 in poorly differentiated and differentiated tumor tissues with lymph node metastasis or tumor cell differentiation was significantly higher than that without lymph node metastasis or well differentiated cells (high or moderately differentiated) (P <0.05). The positive rate of CA242 in advanced tumors was also significantly higher than that in early stage (P <0.05). Conclusion Preoperative determination of CA242 can help determine the presence or absence of lymph node metastasis and tumor progression and staging in colorectal cancer.