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磺胺药引起的神经系统副作用临床上常见有恶心、呕吐、眩晕、头痛、步态不稳及周围神经病等。而致神经系统脱髓鞘性病变尚属少见,作者遇到口服复方新诺明(TMP-SMZ)后所致急性播散性脑脊髓炎1例,报告如下。患者,男,37岁,1991年1月1日入院。10天前因头痛、咽部不适及轻咳,服复方新诺明每次2片,每日三次共20片。服药当日即发生口腔粘膜、阴茎龟头及阴囊皮肤血疱,四肢皮肤散在瘀班。第3天发热、头痛,恶心呕吐,双上肢肌肉疼痛,双下肢麻木,腹胀及排尿困难。第7天高热、昏睡时有喊叫,频频呃逆,上肢震颤、下肢瘫痪及尿潴留,遂来院诊治。既往常因“感冒”服复方新诺明,但从未发生任何
Nausea, vomiting, dizziness, headache, unsteady gait and peripheral neuropathy are common clinical side effects caused by sulfa drugs. The demyelinating nervous system caused by nervous system is still rare, the authors encountered oral compound cotrimoxazole (TMP-SMZ) caused by acute disseminated encephalomyelitis in 1 case, the report is as follows. Patient, male, 37 years old, admitted to hospital on January 1, 1991. 10 days ago due to headache, throat discomfort and light cough, serving comfiroban two tablets each time, a total of 20 tablets three times a day. Oral mucosa, penis glans and scrotal skin blood blisters occurred on the day of medication, limbs and skin scattered in stasis class. Day 3 fever, headache, nausea and vomiting, double upper extremity muscle pain, numbness of lower extremities, bloating and difficulty urinating. The first 7 days of fever, drowsiness, shouting, frequent hiccups, upper limb tremors, lower limb paralysis and urinary retention, then to hospital for treatment. In the past, because of the “cold” service, we did not have anything new