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目的探讨老年2型糖尿病患者冠脉钙化积分与血清护骨素水平的相关性。方法 45例老年2型糖尿病住院患者随机分为2组,冠脉钙化积分正常组和冠脉钙化积分异常组,采用两样本t检验比较不同冠脉钙化积分分组间血清护骨素水平的差异,采用多元线性回归分析老年2型糖尿病患者冠脉钙化积分的影响因素。结果老年2型糖尿病患者冠脉钙化积分异常组的血清护骨素水平(4.07±0.61)ng/L高于冠脉钙化积分正常组(2.78±0.59)ng/L,差异有统计学意义(P<0.05),血清护骨素水平、高密度脂蛋白、三酰甘油是冠脉钙化积分的影响因素(P<0.05)。结论血清护骨素水平与老年2型糖尿病患者大血管并发症相关联,护骨素在老年2型糖尿病患者大血管并发症的发生发展中起一定作用。
Objective To investigate the relationship between coronary calcium score and serum levels of osteoprotegerin in elderly type 2 diabetic patients. Methods Forty-five elderly patients with type 2 diabetes mellitus were randomly divided into two groups: normal coronary artery disease group and normal coronary artery disease group. Two-sample t-test was used to compare the difference of serum osteoprotegerin level among different coronary artery disease group, Factors influencing coronary calcium score in senile type 2 diabetic patients by multivariate linear regression analysis. Results The serum level of osteoprotegerin (4.07 ± 0.61) ng / L in ACS group was significantly higher than that in ACS group (2.78 ± 0.59) ng / L, the difference was statistically significant (P <0.05). The levels of serum osteoprotegerin, high density lipoprotein and triglyceride were the influential factors of coronary calcium score (P <0.05). Conclusion The serum level of osteoprotegerin is associated with macrovascular complications in elderly type 2 diabetic patients. Osteoprotegerin may play a role in the development of macrovascular complications in elderly type 2 diabetic patients.