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目的探讨Survivin在食管癌组织中的表达及其与bcl-2蛋白表达的相关性。方法应用免疫组织化学SP法,检测Survivin、bcl-2蛋白在68例食管癌组织和20例正常食管组织中的表达。结果Survivin蛋白在正常食管组织中低表达或不表达,68例食管癌组织中,49例表达阳性,占72.1%。Survivin蛋白表达与分化程度、淋巴结转移密切相关(P<0.05)。食管癌组织bcl-2蛋白表达阳性、阴性组中,Survivin蛋白阳性表达率分别为94.7%(36/38)和43.3%(13/30),两者比较,差异有统计学意义(P<0.05)。Survivin蛋白表达与bcl-2蛋白表达密切相关。结论Survivin在食管癌组织中表达上调,通过抑制细胞凋亡,在食管癌的发生中起到重要作用;凋亡相关基因bcl-2的上调与Survivin的表达可能在食管癌变中起协同作用。
Objective To investigate the expression of survivin in esophageal carcinoma and its relationship with bcl-2 protein expression. Methods Immunohistochemical SP method was used to detect the expression of Survivin and bcl-2 protein in 68 cases of esophageal cancer tissues and 20 cases of normal esophageal tissues. Results Survivin protein was low or not expressed in normal esophageal tissues. Of the 68 esophageal cancer tissues, 49 were positive, accounting for 72.1%. Survivin protein expression was closely related to the degree of differentiation and lymph node metastasis (P <0.05). The positive rates of bcl-2 protein in esophageal cancer tissues were 94.7% (36/38) and 43.3% (13/30), respectively. There was significant difference between the two groups (P <0.05 ). Survivin protein expression and bcl-2 protein expression are closely related. Conclusions Survivin is upregulated in esophageal carcinoma and plays an important role in the development of esophageal carcinoma by inhibiting apoptosis. The up-regulation of bcl-2 and the expression of Survivin may play a synergistic role in esophageal carcinogenesis.