论文部分内容阅读
目的探讨老年2型DM患者血清胱抑素C(Cys C)水平与颈动脉内中膜厚度(IMT)之间的关系。方法应用颈动脉超声波测定DM2患者IMT水平,采用化学发光法检测患者血浆Csy C水平,同时测定空腹血糖(FPG)、肌酐(Scr)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)以及体质指数(BMI)。结果①DM组血浆Cys C的平均水平高于正常对照组,DM组患者高Cys C血症的发病率高于正常对照组;②血浆CysC水平与BMI、DM病程、血脂水平不相关;③高Cys C血症是老年2型DM患者IMT增厚的危险因素。结论老年2型DM患者Cys C水平升高,可作为预测2型DM患者大血管病变发生与发展的评价指标。
Objective To investigate the relationship between serum cystatin C (Cys C) level and carotid artery intima - media thickness (IMT) in elderly type 2 DM patients. Methods The level of IMT in DM2 was measured by carotid ultrasonography. The level of Cys C in plasma was measured by chemiluminescence method. The levels of fasting plasma glucose (FPG), creatinine (Scr), triglyceride (TG), total cholesterol (TC) Lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), and body mass index (BMI). Results ① The mean level of plasma Cys C in DM group was higher than that in normal control group. The incidence of hypercysteric hyperlipidemia in DM group was higher than that of normal control group. ② The level of plasma CysC was not correlated with BMI, DM course and blood lipid level. Hyperlipidemia is a risk factor for IMT thickening in elderly type 2 DM patients. Conclusion The elevated level of Cys C in elderly type 2 DM patients can be used as an index to predict the occurrence and development of macrovascular disease in type 2 DM patients.